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It is because adding supplemental ingredients allows compounders to argue their product is not a copy of the FDA-approved drug, which creates a legal pathway to continue compounding

No significant effect on ACTH stimulation

In an alcohol-instilled rat model, gastric, esophageal, and duodenal lesions develop alongside loss of left gastric artery vessel presentation

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NTZ at 100 mg/kg failed to alleviate hepatic histopathology scoring significantly (Figures 8BD), which is in alignment with the features displayed in photomicrographs of H&E-stained liver sections where moderate hepatoportal and sinusoidal congestion, moderate periportal inflammatory infiltrate, and moderate hepatocytes necrosis were found